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chia seeds drug interactions

Chia seeds drug interactions

Chía, Chia Fresca, Chia Grain, Chia Oil, Chia Seed, Chia Sprout, Germe de Chia, Graine de Chia, Graine de Salba, Huile de Chia, Pinole, S. Hispanica, Salba, Salba Grain, Salvia hispanica, Salvia Hispanica L.

What is Chia?

When you hear “chia,” you may think of “Chia Pets.” These are clay figures sold in the US that support the growth of chia sprouts. But chia has a much longer history as a medicinal herb. It originated in Mexico and was cultivated by the Aztecs. Today, chia is grown commercially in Central America and South America. It is grown mainly for its seed, which is a rich source of omega-3 fatty acids.

People use chia seed for diabetes, improving exercise performance, high blood pressure, reducing the risk of heart disease, reducing a group of conditions that increase the risk of heart disease, and weight loss.).

Chia is applied to the skin for itchy skin (pruritus).

Possibly Ineffective for.

  • Weight loss. Consuming chia seeds mixed with water twice daily before meals for 12 weeks does not improve body composition or reduce blood pressure in people who are overweight or obese. Also, eating milled or whole chia seeds daily for 10 weeks does not improve body composition or blood pressure in overweight women.

Insufficient Evidence to Rate Effectiveness for.

  • Diabetes. People who have diabetes are more likely than other people to develop heart disease and stroke. Some early research shows that people with diabetes can lower their high risk by eating bread that contains a particular type of chia called Salba (Salba Nutritional Solutions). The dose of Salba that is needed to lower heart disease and stroke risk is 37 grams per day for 12 weeks. This dose seems to reduce blood pressure and lower the levels of C-reactive protein and von Willebrand factor in the blood. C-reactive protein is a “marker” for inflammation, a process that some researchers think is responsible for some forms of heart disease. Less C-reactive protein means there is less inflammation. Von Willebrand factor is involved in blood clotting. Less von Willebrand factor may mean that fewer clots that could cause a heart attack or stroke are formed. However, eating Salba does not affect all heart disease and stroke risk factors. For example, eating Salba in bread doesn’t seem to lower cholesterol.
  • Exercise performance. Early research suggests that trained athletes who drink a beverage containing 50% of calories from chia seeds (Green Plus Omega 3 Chia seeds) and 50% from Gatorade for 2 days before completing an endurance exercise perform similarly to athletes who drink just Gatorade alone.
  • High blood pressure. Early research suggests that taking 35 grams per day of chia flour for 12 weeks reduces blood pressure in people with high blood pressure. It seems to work best in people already taking medicine to lower their blood pressure.
  • A group of conditions that increase the risk of heart disease (metabolic syndrome). Early research shows that eating 500 fewer calories daily and drinking a beverage containing soy protein, nopal, chia seed, and oat daily for 2 months can reduce body weight, body mass index, and waist circumference in people with metabolic syndrome. However, people who just reduce calorie intake have similar results. Still, drinking the chia beverage seems to lower triglyceride levels and improve blood sugar compared to only reducing calorie intake.
  • Itching. Early research shows that applying lotion containing chia seed oil to the skin for 8 weeks reduces itching.
  • Other conditions. word

More evidence is needed to rate the effectiveness of chia for these uses.

SLIDESHOW

How does Chia work?

Chia seeds contain a large amount of healthy omega-3 fatty acids and dietary fiber. Researchers think omega-3 fatty acids and fiber help reduce risk factors for heart disease.

Are there safety concerns?

Chia is POSSIBLY SAFE Early research shows that applying lotion containing chia seed oil to the skin for 8 weeks reduces itching.

Special Precautions & Warnings:

High blood fats called triglycerides: Blood contains several types of fat, including cholesterol and triglycerides. Triglyceride levels are too high in some people. Eating some types of chia can make them even higher. If you have high triglycerides, stick with using a specific variety of chia called Salba. Salba does not significantly increase triglyceride levels.

Prostate cancer: Chia contains a lot of alpha-linolenic acid. Some research suggests that large amounts of alpha-linolenic acid in the diet might increase the chance of getting prostate cancer. If you have prostate cancer or have a high risk of getting it, avoid eating large amounts of chia.

Dosing considerations for Chia.

The appropriate dose of chia depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for chia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, and Insufficient Evidence to Rate (detailed description of each of the ratings).

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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Ayerza, R., Jr. and Coates, W. Effect of dietary alpha-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma. Ann Nutr Metab 2007;51(1):27-34. View abstract.

Espada, C. E., Berra, M. A., Martinez, M. J., Eynard, A. R., and Pasqualini, M. E. Effect of Chia oil (Salvia Hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. Prostaglandins Leukot.Essent.Fatty Acids 2007;77(1):21-28. View abstract.

Švec I, Hrušková M. Hydrated chia seed effect on wheat flour and bread technological quality. Agric Eng Int 2015;23(4):259-263.

Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22. View abstract.

Chicco AG, D’Alessandro ME, Hein GJ, Oliva ME, Lombardo YB. Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats. Br J Nutr. 2009;101(1):41-50. View abstract.

Estilai A, Hashemi A. Chromosome number and meiotic behavior of cultivated chia, Salvia hispanica (Lamiaceae). Hort Sci 1990;25(12):1646-1647.

Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 2003;77:783-95. View abstract.

García Jiménez S, Pastor Vargas C, de las Heras M, Sanz Maroto A, Vivanco F, Sastre J. Allergen characterization of chia seeds (Salvia hispanica), a new allergenic food. J Investig Allergol Clin Immunol. 2015;25(1):55-6.

Guevara-Cruz M, Tovar AR, Aguilar-Salinas CA, et al. A dietary pattern including nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndrome. J Nutr. 2012;142(1):64-9. View abstract.

Ho H, Lee AS, Jovanovski E, et al. Effect of whole and ground Salba seeds (Salvia Hispanica L.) on postprandial glycemia in healthy volunteers: a randomized controlled, dose-response trial. Eur J Clin Nutr. 2013;67(7):786-8. View abstract.

Illian TG, Casey JC, Bishop PA. Omega 3 Chia seed loading as a means of carbohydrate loading. J Strength Cond Res. 2011;25(1):61-5. View abstract.

Ixtaina VY, Nolasco SM, Tomas MC. Physical properties of chia (Salvia hispanica L.) seeds. Ind Crops Prod 2008;28(3):286-293.

Jeong SK, Park HJ, Park BD, Kim IH. Effectiveness of Topical Chia Seed Oil on Pruritus of End-stage Renal Disease (ESRD) Patients and Healthy Volunteers. Ann Dermatol. 2010;22(2):143-8. View abstract.

Nieman DC, Cayea EJ, Austin MD, et al. Chia seed does not promote weight loss or alter disease risk factors in overweight adults. Nutr Res. 2009;29(6):414-8. View abstract.

Nieman DC, Gillitt N, Jin F, et al. Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. J Altern Complement Med. 2012;18(7):700-8. View abstract.

Toscano LT, da Silva CS, Toscano LT, de Almeida AE, Santos AC, Silva AS. Chia flour supplementation reduces blood pressure in hypertensive patients. Plant Foods Hum Nutr. 2014 Dec;69(4):392-8.

Vuksan V, Whitham D, Sievenpiper JL, et al. Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trial. Diabetes Care 2007;30:2804-10. View abstract.

Pill Identifier Tool Quick, Easy, Pill Identification

Chia seeds drug interactions Chía, Chia Fresca, Chia Grain, Chia Oil, Chia Seed, Chia Sprout, Germe de Chia, Graine de Chia, Graine de Salba, Huile de Chia, Pinole, S. Hispanica, Salba, Salba

Chia seeds drug interactions

When you hear “chia,” you may think of “Chia Pets.” These are clay figures sold in the US that support the growth of chia sprouts. But chia has a much longer history as a medicinal herb. It originated in Mexico and was cultivated by the Aztecs. Today, chia is grown commercially in Central America and South America. It is grown mainly for its seed, which is a rich source of omega-3 fatty acids.

People use chia seed for diabetes, athletic performance, high blood pressure, heart disease, and itching, but there is no good scientific evidence to support these uses.

How does it work ?

Chia seeds contain a large amount of healthy omega-3 fatty acids and dietary fiber. Researchers think omega-3 fatty acids and fiber help reduce risk factors for heart disease.

Uses & Effectiveness ?

Possibly Ineffective for

  • Obesity. Consuming chia seeds mixed with water twice daily before meals for 12 weeks does not seem to reduce body weight or blood pressure in people who are overweight or obese. Also, eating milled or whole chia seeds daily for 10 weeks does appear not improve body weight or blood pressure in overweight women.

Insufficient Evidence for

  • Athletic performance. Early research suggests that trained athletes who drink a beverage containing 50% of calories from chia seeds (Green Plus Omega 3 Chia seeds) and 50% from Gatorade for 2 days before completing an endurance exercise perform similarly to athletes who drink just Gatorade alone.
  • Diabetes. People who have diabetes are more likely than other people to develop heart disease and stroke. Some early research shows that people with diabetes can lose weight and improve some “markers” of heart disease and stroke risk by eating a type of chia called Salba (Salba Smart Natural Products). However, eating Salba does not affect all heart disease and stroke risk factors and does not seem to reduce body fat or blood sugar levels in people with diabetes.
  • High blood pressure. Early research suggests that taking 35 grams per day of chia flour for 12 weeks reduces blood pressure in people with high blood pressure. It seems to work best in people already taking medicine to lower their blood pressure.
  • Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Early research suggests that taking 25 grams per day of ground chia seeds for 8 weeks may reduce the amount of fat in the liver and slightly lower body mass index (BMI).
  • Itching. Early research shows that applying lotion containing chia seed oil to the skin for 8 weeks reduces itching.
  • A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (metabolic syndrome).
  • Other conditions.

More evidence is needed to rate the effectiveness of chia for these uses.

Side Effects

When taken by mouth: Chia is LIKELY SAFE when taken in the amounts found in foods. When consumed in larger amounts, chia is POSSIBLY SAFE when used for up to 6 months. Large doses might cause mild stomach discomfort in some people.

When applied to the skin: Chia is POSSIBLY SAFE Early research shows that applying lotion containing chia seed oil to the skin for 8 weeks reduces itching.

Special Precautions and Warnings

Pregnancy and breast-feeding: There isn’t enough reliable information to know if chia is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Prostate cancer: Chia contains a lot of alpha-linolenic acid. Some research suggests that large amounts of alpha-linolenic acid in the diet might increase the chance of getting prostate cancer. If you have prostate cancer or have a high risk of getting it, avoid eating large amounts of chia.

Interactions ?

We currently have no information for CHIA overview .

Dosing

The appropriate dose of chia depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for chia. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Adams, J. D., Wall, M., and Garcia, C. Salvia columbariae contains tanshinones. Evid.Based.Complement Alternat.Med 2005;2(1):107-110. View abstract.

Adams, J. D., Wang, R., Yang, J., and Lien, E. J. Preclinical and clinical examinations of Salvia miltiorrhiza and its tanshinones in ischemic conditions. Chin Med 2006;1:3. View abstract.

Ayerza, R. and Coates, W. Dietary levels of chia: influence on yolk cholesterol, lipid content and fatty acid composition for two strains of hens. Poult.Sci 2000;79(5):724-739. View abstract.

Ayerza, R. Oil content and fatty acid composition of chia (

Ayerza, R., Jr. and Coates, W. Effect of dietary alpha-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma. Ann Nutr Metab 2007;51(1):27-34. View abstract.

Bushway, A. A., Belyea, P. R., and Bushway, R. J. Chia seed as a source of oil, polysaccharide, and protein. Journal of Food Science 1981;46(5):1349-1350.

Espada, C. E., Berra, M. A., Martinez, M. J., Eynard, A. R., and Pasqualini, M. E. Effect of Chia oil (Salvia Hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. Prostaglandins Leukot.Essent.Fatty Acids 2007;77(1):21-28. View abstract.

Justo, M. B., Alfaro, A. D., Aguilar, E. C., Wrobel, K., Wrobel, K., Guzman, G. A., Sierra, Z. G., and Zanella, Vda M. [Integral bread development with soybean, chia, linseed, and folic acid as a functional food for women]. Arch Latinoam.Nutr 2007;57(1):78-84. View abstract.

Reyes-Caudillo, E., Tecante, A., and Valdivia-LГіpez, M. A. Dietary fibre content and antioxidant activity of phenolic compounds present in Mexican chia (Salvia hispanica L.) seeds. Food Chemistry 2008;107(2):656-663.

Wang, X., Morris-Natschke, S. L., and Lee, K. H. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Med Res Rev 2007;27(1):133-148. View abstract.

Yang, X. F., Wang, N. P., and Zeng, F. D. [Effects of the active components of some Chinese herbs on drug metabolizing-enzymes]. Zhongguo Zhong.Yao Za Zhi. 2002;27(5):325-328. View abstract.

Zhou, L., Zuo, Z., and Chow, M. S. Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol 2005;45(12):1345-1359. View abstract.

Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22. View abstract.

Chicco AG, D’Alessandro ME, Hein GJ, Oliva ME, Lombardo YB. Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats. Br J Nutr. 2009;101(1):41-50. View abstract.

Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 2003;77:783-95. View abstract.

Guevara-Cruz M, Tovar AR, Aguilar-Salinas CA, et al. A dietary pattern including nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndrome. J Nutr. 2012;142(1):64-9. View abstract.

Ho H, Lee AS, Jovanovski E, et al. Effect of whole and ground Salba seeds (Salvia Hispanica L.) on postprandial glycemia in healthy volunteers: a randomized controlled, dose-response trial. Eur J Clin Nutr. 2013;67(7):786-8. View abstract.

Illian TG, Casey JC, Bishop PA. Omega 3 Chia seed loading as a means of carbohydrate loading. J Strength Cond Res. 2011;25(1):61-5. View abstract.

Jeong SK, Park HJ, Park BD, Kim IH. Effectiveness of Topical Chia Seed Oil on Pruritus of End-stage Renal Disease (ESRD) Patients and Healthy Volunteers. Ann Dermatol. 2010;22(2):143-8. View abstract.

Nieman DC, Cayea EJ, Austin MD, et al. Chia seed does not promote weight loss or alter disease risk factors in overweight adults. Nutr Res. 2009;29(6):414-8. View abstract.

Nieman DC, Gillitt N, Jin F, et al. Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. J Altern Complement Med. 2012;18(7):700-8. View abstract.

Vuksan V, Whitham D, Sievenpiper JL, et al. Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trial. Diabetes Care 2007;30:2804-10. View abstract.

Ayerza, R., Jr. and Coates, W. Effect of dietary alpha-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma. Ann Nutr Metab 2007;51(1):27-34. View abstract.

Espada, C. E., Berra, M. A., Martinez, M. J., Eynard, A. R., and Pasqualini, M. E. Effect of Chia oil (Salvia Hispanica) rich in omega-3 fatty acids on the eicosanoid release, apoptosis and T-lymphocyte tumor infiltration in a murine mammary gland adenocarcinoma. Prostaglandins Leukot.Essent.Fatty Acids 2007;77(1):21-28. View abstract.

Brouwer IA, Katan MB, Zock PL. Dietary alpha-linolenic acid is associated with reduced risk of fatal coronary heart disease, but increased prostate cancer risk: a meta-analysis. J Nutr 2004;134:919-22. View abstract.

Chicco AG, D’Alessandro ME, Hein GJ, Oliva ME, Lombardo YB. Dietary chia seed (Salvia hispanica L.) rich in alpha-linolenic acid improves adiposity and normalises hypertriacylglycerolaemia and insulin resistance in dyslipaemic rats. Br J Nutr. 2009;101(1):41-50. View abstract.

EFSA Panel on Nutrition, Novel Foods and Food Allergens (EFSA NDA Panel), Turck D, Castenmiller J, de Henauw S, et al. Safety of chia seeds (Salvia hispanica L.) as a novel food for extended uses pursuant to Regulation (EU) 2015/2283. EFSA J. 2019 Apr 17;17(4):e05657. View abstract.

EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Castenmiller J, et al. Safety of chia seeds (Salvia hispanica L.) powders, as novel foods, pursuant to Regulation (EU) 2015/2283. EFSA J. 2019 Jun 12;17(6):e05716. View abstract.

Estilai A, Hashemi A. Chromosome number and meiotic behavior of cultivated chia, Salvia hispanica (Lamiaceae). Hort Sci 1990;25(12):1646-1647.

Finnegan YE, Minihane AM, Leigh-Firbank EC, et al. Plant- and marine-derived n-3 polyunsaturated fatty acids have differential effects on fasting and postprandial blood lipid concentrations and on the susceptibility of LDL to oxidative modification in moderately hyperlipidemic subjects. Am J Clin Nutr 2003;77:783-95. View abstract.

GarcГ­a JimГ©nez S, Pastor Vargas C, de las Heras M, Sanz Maroto A, Vivanco F, Sastre J. Allergen characterization of chia seeds (Salvia hispanica), a new allergenic food. J Investig Allergol Clin Immunol. 2015;25(1):55-6.

Guevara-Cruz M, Tovar AR, Aguilar-Salinas CA, et al. A dietary pattern including nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndrome. J Nutr. 2012;142(1):64-9. View abstract.

Ho H, Lee AS, Jovanovski E, et al. Effect of whole and ground Salba seeds (Salvia Hispanica L.) on postprandial glycemia in healthy volunteers: a randomized controlled, dose-response trial. Eur J Clin Nutr. 2013;67(7):786-8. View abstract.

Illian TG, Casey JC, Bishop PA. Omega 3 Chia seed loading as a means of carbohydrate loading. J Strength Cond Res. 2011;25(1):61-5. View abstract.

Ixtaina VY, Nolasco SM, Tomas MC. Physical properties of chia (Salvia hispanica L.) seeds. Ind Crops Prod 2008;28(3):286-293.

Jeong SK, Park HJ, Park BD, Kim IH. Effectiveness of Topical Chia Seed Oil on Pruritus of End-stage Renal Disease (ESRD) Patients and Healthy Volunteers. Ann Dermatol. 2010;22(2):143-8. View abstract.

Medina-Urrutia A, Lopez-Uribe AR, El Hafidi M, et al. Chia (Salvia hispanica)-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans. Lipids Health Dis. 2020 May 19;19(1):96. View abstract.

Nieman DC, Cayea EJ, Austin MD, et al. Chia seed does not promote weight loss or alter disease risk factors in overweight adults. Nutr Res. 2009;29(6):414-8. View abstract.

Nieman DC, Gillitt N, Jin F, et al. Chia seed supplementation and disease risk factors in overweight women: a metabolomics investigation. J Altern Complement Med. 2012;18(7):700-8. View abstract.

Svec I, HruskovГЎ M. Hydrated chia seed effect on wheat flour and bread technological quality. Agric Eng Int 2015;23(4):259-263.

Toscano LT, da Silva CS, Toscano LT, de Almeida AE, Santos AC, Silva AS. Chia flour supplementation reduces blood pressure in hypertensive patients. Plant Foods Hum Nutr. 2014 Dec;69(4):392-8.

Vuksan V, Choleva L, Jovanovski E, et al. Comparison of flax (Linum usitatissimum) and Salba-chia (Salvia hispanica L.) seeds on postprandial glycemia and satiety in healthy individuals: a randomized, controlled, crossover study. Eur J Clin Nutr 2017;71(2):234-8. View abstract.

Vuksan V, Jenkins AL, Brissette C, et al. Salba-chia (Salvia hispanica L.) in the treatment of overweight and obese patients with type 2 diabetes: a double-blind randomized controlled trial. Nutr Metab Cardiovasc Dis 2017;27(2):138-46. View abstract.

Vuksan V, Whitham D, Sievenpiper JL, et al. Supplementation of conventional therapy with the novel grain Salba (Salvia hispanica L.) improves major and emerging cardiovascular risk factors in type 2 diabetes: results of a randomized controlled trial. Diabetes Care 2007;30:2804-10. View abstract.

Learn more about CHIA uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain CHIA.