CBD Oil Guide

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CBD Beginners Guide: How To Get Started With CBD Oil CBD Oil has become increasingly popular in recent times, and you can now find CBD products in various stores or even buy CBD online. It’s often used as a natural supplement for those who want to consume cannabinoids or want a legal, high-free … Pharmacist’s Guide to CBD Oil ABSTRACT: Cannabidiol (CBD) is becoming more prevalent, and pharmacists must be knowledgeable about these products in order to counsel patients effectively. CBD

CBD Oil Guide

CBD Oil has become increasingly popular in recent times, and you can now find CBD products in various stores or even buy CBD online. It’s often used as a natural supplement for those who want to consume cannabinoids or want a legal, high-free alternative to cannabis. However, there are many people out there who are most likely wondering how to get started with CBD Oil.

Fortunately, CBD Oil is safe, natural, and easy to use. However, if you’ve never tried it before, you probably have questions about which product to choose, how much you should use, and what to expect when you use it. As such, our CBD Beginner’s Guide will walk you through everything you need to know about getting started with CBD Oil.

What Is CBD Oil?

CBD Oil is a natural, cannabinoid-based product made by extracting cannabidiol from hemp plants into a consumable liquid form. Cannabidiol is one of the many cannabinoids that can be found in cannabis and hemp plants, although extracting it from hemp helps to keep CBD products low in THC and free from psychoactive effects.

Many people now use CBD Oil as a safe and natural alternative to cannabis. CBD Oil won’t get you high, nor will it give you any intoxicating effects. However, many people still turn to CBD Oil as an alternative to cannabis, especially if they’re looking for a product that allows them to consume cannabinoids without any harsh side effects.

It’s often used as a daily supplement, much like you’d use a multivitamin or other supplements for general wellness. Although there are many other CBD products out there, many people choose CBD Oil as it allows you to absorb CBD into your system quickly and conveniently. There are also multiple ways to use it, making it a versatile product that can suit all kinds of users.

Where To Buy CBD Oil

Due to the rapidly-growing popularity of CBD Oil, it can now be found in many places. You might find CBD Oil in health stores or even in your local grocery store. However, many of the CBD products you’ll find in stores are low-quality and won’t give you the best results. Instead, it’s best to buy CBD Oil from a trusted seller.

Wonderbuds is an Ontario Authorized cannabis dispensary that offers a range of certified CBD products from top brands. You can either pick up your CBD products in our Niagara Falls store or even make an online order. Whichever way, you can rely on premium products that are tested to ensure the utmost quality.

There are many popular options to choose from when it comes to CBD Oil. For instance, you might want to try Symbl High CBD Oil, Edison Cannabis Co. CBD Oil, or Reef Tranquil CBD Oil. You can also find various other CBD Oil products or even buy other types of CBD and cannabis products.

How To Use CBD Oil

The most common way to use CBD Oil is to apply it under your tongue. This method is fast, effective, and allows CBD to reach your system within around 30 minutes. It also makes it easy to use CBD Oil pretty much anywhere, even if you’re in your car or on the go.

Start by measuring your desired dose of CBD Oil using the dropper provided. Then carefully apply the drops under your tongue and hold them there for around 30-90 seconds. The CBD will be absorbed into your system by the mucous membrane of your tongue. This method is also known as sublingual absorption.

CBD Oil can also be ingested orally. While you might not want to swallow CBD Oil by itself, you can add it to foods such as soup, salad, or even apply drops on top of a regular snack or meal before eating it. However, keep in mind that you shouldn’t cook with CBD Oil, and consuming it orally takes longer to work than sublingual absorption.

You can also add CBD Oil to drinks. This is an easy and refreshing way to get a daily dose of CBD Oil, especially as you can add it to your tea, coffee, or even smoothies and juices. Simply measure your desired dosage, add the drops to your beverage, and mix before drinking. Much like mixing CBD Oil with your food, this method isn’t as fast as sublingual absorption but still works well.

How Much CBD Oil Should You Use?

Currently, there is no official recommended dosage for CBD. Fortunately, research suggests that CBD is very safe to use, even when used frequently or in high doses, and you won’t need to worry about taking too much. With that said, there are some general guidelines on how much you should take.

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If you’re using CBD Oil for general purposes, it’s best to use a daily dose of around 10 to 20 mg a day. With that said, you can feel free to increase the dosage by 10mg each time if you feel that you need more or find it more comforting.

Each CBD Oil product is different, so you’ll need to check how potent it is and how much CBD is in each serving. Usually, CBD Oil is measured in mg and each drop from the dropper provided will give you a certain amount. This makes it easy to measure your desired dosage with the dropper and either apply it under your tongue or add it to your food or drink to consume it orally.

Getting started with CBD Oil is easy. You can buy CBD Oil online and use it either by applying it under your tongue or adding it to your food or drink. Whichever way, it’s very safe to use and many people take a daily dose of CBD just as they would with other kinds of natural supplements.

If you’re looking for high-quality CBD Oil products, make sure you check out Wonderbuds. In addition to CBD Oil, you can also find other CBD products including CBD Isolate, CBD Topicals, and even CBD Tea. You can also find a wide range of cannabis products including strains, concentrates, vape products, and more.

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Pharmacist’s Guide to CBD Oil

ABSTRACT: Cannabidiol (CBD) is becoming more prevalent, and pharmacists must be knowledgeable about these products in order to counsel patients effectively. CBD laws and regulations are determined at the state level in the United States. Non–FDA-approved CBD products are not regulated and may contain harmful chemicals. Pharmacists must counsel patients on where and how to obtain products and to check the amount of CBD and delta-9-tetrahydrocannabinol in the product. CBD has numerous drug interactions that should be evaluated by a pharmacist. CBD is most promising for treatment-resistant seizures, and more research is necessary to evaluate its use for other indications. Sativex is currently being investigated in the U.S. for treatment of spasticity associated with multiple sclerosis and schizophrenia. In general, more studies of CBD are needed.

Cannabidiol (CBD) is gaining popularity across the United States. Pharmacists must be able to answer patients’ questions about CBD and make recommendations. This article will provide specific information about CBD, including laws, how to select a non–FDA-approved CBD product, indications for use, side effects and warnings, drug interactions, dosing and directions, pharmacokinetics, and the future of CBD oil. After reading this article, pharmacists should feel confident about counseling patients about CBD and recommending CBD products.

Laws Concerning CBD

CBD was first isolated from the Cannabis sativa plant in the 1930s. CBD is a nonpsychoactive part of the plant, whereas delta-9-tetrahydrocannabinol (THC) is the major psychoactive part of the plant. In the 1970s, researchers evaluated CBD as a pharmacologic agent. 1 Epidiolex, a 100 mg/mL oral solution with less than 0.01% THC, became the first FDA-approved CBD-containing drug in June 2018. 2 The drug is Schedule V and indicated only as an anticonvulsant for Lennox-Gastaut syndrome or Dravet syndrome in patients aged 2 years and older. 3

In December 2018, the Agriculture Improvement Act, which removed hemp from Drug Enforcement Administration (DEA) regulation as a controlled substance, was passed and signed into U.S. law. Hemp is defined as a cannabis plant that contains no more than 0.3% THC. (In contrast, marijuana has a higher THC.) Hemp is now regulated by the U.S. Department of Agriculture and is legal in all 50 states. Laws and restrictions regarding the selling of hemp products vary by state, making it questionable to travel with CBD products. 2

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U.S. laws and regulations concerning CBD are determined at the state level. Currently, 33 states have legalized CBD use for medical purposes, and 10 states (Alaska, California, Colorado, Maine, Massachusetts, Michigan, Nevada, Oregon, Vermont, and Washington) and the District of Columbia have legalized marijuana for recreational use. In states such as New York, Minnesota, and Connecticut, pharmacists are required to dispense the products in authorized dispensaries. Marijuana-derived CBD oil is still considered illegal under the Controlled Substances Act in accordance with the DEA’s classification of marijuana as a Schedule I substance. 2

Selecting a Non–FDA-Approved CBD Product

Pharmacists must educate patients about how to select an appropriate non–FDA-approved CBD product. These products are not tested for safety, efficacy, or quality. 4 The main concerns in picking a non–FDA-approved CBD product are that it may contain harmful chemicals and may not accurately list the correct amounts of CBD and THC it contains. These products could contain harmful contaminants (e.g., pesticides, heavy metals) or have high levels of THC, which would result in a positive urine drug test. 5 The patient should be advised to obtain CBD products from a medical dispensary because these products are regulated. The patient should also consider ordering products from states where CBD is legal because more testing is done in those states. When selecting a product, the patient should check the label to see if it lists the amount of CBD in each dose. 5,6 The manufacturer should provide a Certificate of Analysis, which shows an independent laboratory’s assessment of the product’s potency and the presence of contaminants. 5 When assessing quality, the patient should look for the Hemp Authority seal, which means that the product is legal and the manufacturer is adhering to quality standards. 7

Indications for CBD

As consumer demand in the U.S. has risen, along with the number of dispensaries, the number of studies addressing the therapeutic effects of CBD has increased. The studies performed, however, are insufficient; large randomized, placebo-controlled trials need to be conducted. CBD seems most promising for treatment-resistant seizures. There is limited evidence concerning the use of CBD for psychotic symptoms in Parkinson’s disease and for anxiety related to public speaking. CBD has not been proven effective for pain, nausea, or depression. 4 THC, conversely, is thought to be effective for these conditions because it has a different mechanism of action. THC activates the CB1 and CB2 receptors in the brain, and CBD does not. As mentioned previously, CBD does not have psychotropic effects and THC does. These differences are believed to account for the different uses of CBD and THC. 7,8

Patients with early-onset epilepsy who are resistant to conventional therapy may benefit from CBD oil. A trial that investigated the effect of CBD on drop seizures of Lennox-Gastaut syndrome found that CBD 10 mg/kg/day or 20 mg/kg/day, when added to conventional therapy, led to a greater reduction of drop seizures compared with placebo. 9 The most common adverse reactions were somnolence, decreased appetite, and diarrhea. Specific adverse events from CBD included elevated liver aminotransferase concentrations. 9

Clinical findings on the use of CBD oil in Parkinson’s disease (PD) remain unclear. Past studies have evaluated CBD’s efficacy in minimizing nonmotor symptoms of PD, such as cognitive deficits, sleep disturbances, psychosis, depression, and anxiety. 10 The neuroprotective properties of CBD have been studied in animals with PD, with results indicating that CBD appears to reduce psychotic symptoms. 11 Although patients with PD have reported fewer sleep disturbances as well as improvements in quality of life, treatment in humans requires further investigation on a larger scale, with longer durations and more standardized dosing. 12 Most studies have used combinations of CBD and THC extracts, including nabilone, a synthetic CB1 receptor agonist. CBD dosages of 150 mg/day for 4 weeks and titrated by 140 mg/week were found to be safe and well tolerated and did not worsen motor function. 10

More evidence is needed to support the use of CBD for anxiety. Studies have found that CBD 300 mg may be effective for anxiety related to public speaking, and doses of 400 mg to 600 mg may help patients with social anxiety disorder and public speaking–related anxiety. Studies are inconclusive concerning the utility of CBD for anxiety. 13

Side Effects and Warnings

Studies have reported various properties and potential benefits of CBD. Some undesired side effects of CBD use are decreased appetite, dry mouth, diarrhea, dizziness, drowsiness, fatigue, lightheadedness, orthostatic hypotension, psychomotor slowing, sedation, somnolence, weight loss, and increased risk of liver injury with dosages of 20 mg/kg/day or the use of clobazam or valproate. Monitoring of liver enzymes, weight, and cognitive function may be warranted. CBD can pass through the placenta, so it is recommended that CBD be avoided during pregnancy and while breastfeeding. Because CBD oils may contain trace amounts of THC, operating heavy machinery and driving should be avoided when treatment is initiated. 1

Drug Interactions

CBD is metabolized in the liver, mainly by CYP2C19, CYP3A4, and UGT. This can lead to interactions with prescription drugs, OTC medications, and herbal supplements. 1,14

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The inhibition of CYP2C19 by CBD can increase levels of carisoprodol, citalopram, clopidogrel, diazepam, phenytoin, proton pump inhibitors (PPIs), valproic acid, and warfarin. As a strong CYP3A4 inducer, CBD may lessen the efficacy of amlodipine, atorvastatin, buprenorphine, bupropion, diltiazem, eplerenone, fentanyl, loperamide, midazolam, paclitaxel, pioglitazone, sildenafil, solifenacin, tamsulosin, testosterone, topiramate, zolpidem, and other 3A4 substrates. 7

More serious effects may occur with concomitant use of central nervous system depressants, such as barbiturates, benzodiazepines, fentanyl, morphine, and propofol. These effects are the result of the synergistic effects of sedation and hypnotic effects at high doses. Increased sedative effects may also be seen with herbal supplements, including kava, melatonin, S-adenosylmethionine, and St. John’s wort. 13,14

Other interactions to be aware of are presented in TABLE 1.

Dosing and Directions

In unregulated dispensaries, CBD oil sold comes in a sublingual formulation known as CBD tincture and is generally available in 30-mL bottles with dropper caps. 15 A bottle costs approximately $20. The concentration of the tincture ranges from about 1,500 mg to 3,000 mg per bottle. If a drop equals 0.05 mL, one bottle contains approximately 600 drops of CBD oil. Drops are usually placed under the tongue, and the patient should let the oil absorb into the lining of the mouth, without swallowing, for 30 seconds to 1 minute. Capsules and gummies are also available. 15

Epidiolex Dosing

As noted earlier, Epidiolex (CBD) is an FDA-approved oral solution for treatment of seizures associated with Lennox-Gastaut syndrome or Dravet syndrome. The cost of Epidiolex is approximately $2,708 per month. It is supplied as 100 mL of solution containing CBD 100 mg/mL. For both indications, the initial starting dosage is 2.5 mg/kg orally twice daily for 1 week. The dosage may be titrated weekly in increments of 2.5 mg/kg twice daily to a maintenance dosage of 5 mg/kg twice daily. The maximum dosage is 10 mg/kg twice daily or 20 mg/kg/day. Gradual tapering is recommended when Epidiolex is discontinued. 3

Starting at a low dosage is recommended for elderly patients and patients with moderate or severe hepatic impairment. The dosage should be 1.25 mg/kg to 5 mg/kg twice daily or 0.5 mg/kg to 2 mg/kg twice daily, respectively. 3

Pharmacokinetics

CBD reaches its maximum concentration in 2.5 to 5 hours. High-calorie and high-fat meals can increase the maximum concentration of drug fivefold and the AUC fourfold. 14 Owing to the first-pass effect, CBD is poorly absorbed, with a bioavailability of 13% to 19%. Better bioavailability has been reported with inhaled CBD (11% to 45%). CBD is 94% protein bound; therefore, interactions may occur with other highly protein bound drugs or in patients who have abnormal albumin levels. The volume of distribution is 20,963 L to 42,849 L, meaning that the drug is largely distributed into the tissues. CBD is metabolized by the gut and primarily by the liver. Epidiolex has an active metabolite, 7-OH-CBD, and is a 2C19 and 3A4 substrate and inhibitor of 2C19, 1A2, UGT1A9, and UGT2B7. Its elimination half-life is 56 to 61 hours. CBD is excreted primarily in the feces and urine. 3

The Future of CBD

Sativex (nabiximols) is an oromucosal spray that contains CBD and THC in a 1:1 ratio. The active ingredients are absorbed sublingually or buccally. Sativex is currently under investigation in the U.S.; however, more than 25 countries worldwide have approved Sativex for the treatment of spasticity associated with multiple sclerosis. Sativex is also being researched for potential treatment of schizophrenia and other conditions. 16

The Pharmacist’s Role

Some pharmacists are hesitant to get involved with CBD. Prosecution by federal law could lead to severe consequences, including fines, imprisonment, or loss of DEA registration for pharmacies, ultimately stripping them of their ability to dispense controlled substances. If U.S. laws and regulations were more uniform across states, many of the concerns surrounding CBD would be eliminated. Until then, patients must use caution when selecting a product from an unregulated source because of the possibility of contamination and product misbranding. 17 Although more testing is needed, it is imperative for pharmacists to understand what to recommend to patients. Pharmacists should counsel patients on the risks and benefits of treatment. Patients who are are using CBD should be reminded to obtain the product from a reputable manufacturer. 17

Conclusion

Pharmacists need to keep abreast of current information on CBD in order to assist patients who are interested in using it. While most studies are inconclusive, there currently is enough information to effectively guide patients in choosing a treatment. CBD has the most evidence for treatment-resistant seizures; other indications need further study. Patients must be counseled to choose an appropriate product from a reputable source. CBD may be misbranded or contaminated with harmful chemicals. Pharmacists are uniquely positioned to assess the numerous potential drug interactions with CBD. New prescription CBD products are currently being investigated in the U.S.

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