CBD Oil For Trigeminal Neuralgia

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Trigeminal Neuralgia (TN) is a chronic pain condition that affects the trigeminal nerve, which carries sensation from your face to your brain. CBD can ease neuropathic pain through its interaction with the endocannabinoid system. Does it mean you can successfully treat trigeminal neuralgia with CBD oil? Let’s shed more light on the mechanism of action. Does the pain brought by trigeminal neuralgia bother you? Perhaps you want to consider using CBD oil to manage your symptoms and improve your quality of life.

Trigeminal neuralgia: How cannabis can help with the excruciating pain

Although it is rare, approximately 1 in 10,000 people develop this condition each year.

The main symptom of trigeminal neuralgia is a sudden attack of severe, sharp, shooting facial pain. The pain may last only a few seconds to a few minutes, but can occur repeatedly, during an attack. The pain is often described as excruciating, like an electric shock. The attacks can be so severe that you’re unable to move while they’re happening. Pain can also arise in other areas that are supplied by the trigeminal nerve, such as the cheek, jaw, eye and forehead.

Initially, it can present itself as short, slight pain, but TN can develop and have more enduring impacts, which can take the form of longer-lasting, more intense pain. The condition affects more women than men and is more likely to affect people who are over 50.

Helen, a patient at Integro Medical Cannabis Clinics, recounts her story from first using conventional medicines to receiving her medical cannabis prescription. Since then, she has seen a significant improvement in her quality of life.

At Integro Clinics, our doctors have seen the positive benefits that cannabis medicines can have in managing our patient’s symptoms of trigeminal neuralgia.

Trigeminal Neuralgia: Helen’s Story

Helen began to suffer from TN 15 years ago, which has meant that she has been unable to work since completing her master’s degree at university. Chronic back pain, which then spread up to her neck, triggered Helen’s TN, which began with agonising migraines.

Helen describes her pain as always starting on the left side of her face.

“Trigeminal neuralgia comes as a permanent headache around my left eye, it feels like I actually have pain in my eye. The pain spreads into my forehead and my jaw as well. It is a constant, mild pain, but if my neck gets stiff, or if I get stressed, it becomes a more severe pain. My TN means I’m light sensitive and I can only use the computer for short periods at a time. If I am looking at the screen for too long, my headaches get worse, and then as a result the pain in my face flares up.” – Helen

Helen was prescribed anticonvulsants by her doctor, such as pregabalin. She did not find that they eased the pain and they caused short term memory loss.

She added: “When I came off the pregabalin tablets, I realised that they had not actually helped me. I was still feeling the same pain as when I was on the medicine. The only thing that changed was that my short term memory started to get better.”

Helen wanted to find an alternative way to manage her pain but did not want to suffer the side effects of using conventional medicines again. After searching through Facebook pages on TN, Helen found out that medical cannabis was legal and available on prescription and could actually help her without any horrible side effects.

“I eventually discovered that cannabis clinics existed on Facebook. I started as a patient at one clinic, but I soon realised that the oil they prescribed wasn’t working for me. So, I then became a patient at Integro and this is where I started to see the benefits of medical cannabis. The team at Integro really helped me to find the best combination of THC and CBD that works for me. I felt like I was listened to and they wanted to help me, rather than just seeing me as being a fussy patient.

The CBMP’s that I’m taking now has made a huge difference in my life. They relax the muscles in my neck which means that my TN is triggered far less than before. I also get a better night’s sleep which in turn reduces the symptoms of my TN. Even though the pain is still there, it’s much less severe, I can actually read a book or look at my computer screen for longer than I could before. Cannabis has really given me my life back.” – Helen

Chornic pain and cannabis

Dr Anthony Ordman, Senior Consultant at Integro Medical Clinics, has seen how cannabis medicines can help patients suffering from TN. The cannabis helps them to manage their symptoms and relieve their pain so they can get on with activities such as reading, or working on a computer screen

“In trigeminal neuralgia, nerve cells fire off in an uncontrolled way which sends pain signals to the brain, experienced as severe pain in the face and mouth.

“Only one conventional medicine will help, carbamazepine, which doesn’t always help completely. Cannabis medicines help to settle down the over-excited nerves and to dampen down their excessive firing. But then it also helps with the secondary effects of TN such as muscle tension, low mood, poor sleep and so on.”

He added: “At Integro Clinics, we aim to never cause any adverse effects or dependency, but the same can’t be said for conventional medicines. Integro Medical Clinics Ltd always recommends remaining under the care and treatment of your GP and specialist for your condition, while using cannabis-based medicines, and the Integro clinical team would always prefer to work in collaboration with them.”

If you would like further information or to speak to Dr Anthony Ordman please contact Integro Clinics:

CBD Oil for Trigeminal Neuralgia: Is Cannabis a Viable Approach?

Neuropathic pain has many faces, one of which includes trigeminal neuralgia. This condition affects the nerves that transmit sensation from the face to the brain, causing severe discomfort comparable to an electric shock. The TN pain can be triggered by the slightest movement or touch anywhere on the face, commonly affecting the lips, gums, jaw, and cheeks.

People with trigeminal neuralgia usually suffer from flare-ups affecting one side of the face at a time. Although short-lived at the beginning, the episodes of burning sensation may become chronic, lasting for weeks or longer.

CBD has been mentioned by researchers as a potentially viable remedy for pain that is difficult to treat. Trigeminal neuralgia fits within this definition like a glove.

Today we’ll elaborate on the problem of TN pain and how to treat it with natural resources.

CBD Oil for Trigeminal Neuralgia: Highlights

  • Trigeminal Neuralgia (TN) develops as a result of the damage caused to the trigeminal nerve, causing severe pain on the face.
  • CBD’s interaction with the endocannabinoid system (ECS) may provide relief from neuropathic pain by mitigating the pain signals. According to a study published in Pharmacological Reviews, CBD strengthens nerve impulses in the ECS receptors, producing analgesic effects (1).
  • A review of studies concluded that topical CBD might be useful in reducing neuropathic pain and sensitivity to pain signals (hyperalgesia) (2).
  • Researchers have reported that hypertension (high blood pressure) increases the risk of trigeminal neuralgia. In a 2017 study, subjects who received CBD showed reduced resting blood pressure (3).
  • More clinical studies on humans are needed to support the preclinical findings of CBD’s benefits for people with trigeminal neuralgia.

Why People Are Turning to CBD for Trigeminal Neuralgia?

The dysfunction of the trigeminal nerve can have debilitating consequences for the sufferers. It causes severe pain on the face that occurs upon even the slightest movement, such as touching, scratching, or rubbing. The condition may also cause muscle spasms and burning sensations on top of the shock-like pain.

The treatment of trigeminal neuralgia usually involves anticonvulsant medications, antispasmodic agents, surgery, and other procedures involving the trigeminal nerve. Antiepileptic drugs, such as carbamazepine and gabapentin have been used with some success, although they lack efficacy and intolerability with prolonged use.

This is where CBD starts to shine.

Studies on CBD and Trigeminal Neuralgia

CBD is an acknowledged antiepileptic treatment. Its anticonvulsant and neuroprotective properties have been recently posted in a study from the journal Molecules. These actions might be useful in reducing muscle spasms in TN patients (4).

Although studies haven’t analyzed the efficacy of CBD on spasms caused by TN, there is evidence that CBD may have significant benefits for treating chronic pain caused by the condition.

One review has pointed to CBD as the potential reliever of hyperalgesia (pain sensitivity). The review mentioned that CBD can effectively block the pain pathway’s neural transmission. The authors also highlighted the nociceptive effects of cannabinoids, describing them as the potential therapeutic approach to the management of TN pain.

The painkilling and anti-hyperalgesia effects of CBD were supported by an animal study published in the Journal of Experimental Medicine. The study suggested that CBD reduced pain and inflammation caused by neuropathy.

Neuropathy stems from dysfunction or damage in the nerves that may trigger pain, tingling sensation, muscle weakness, and numbness.

On top of the above findings, the authors of the study added that CBD was able to curb hyperalgesia in mice models. There was a conclusion that CBD reduced persistent inflammation and neuropathic pain.

Another paper from the European Journal of Pharmacology demonstrated remarkable anti-inflammatory and immunomodulatory effects of CBD. Cannabidiol was administered to rats with induced sciatic nerve pain. The research team found that CBD treatment lowered inflammation and reduced hyperalgesia (5).

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Experts hypothesize that trigeminal nerve pain can be caused by the contraction of blood vessels in the trigeminal nerve. This contraction damages the trigeminal protective tissue. Furthermore, researchers noticed that high blood pressure contributes to the development of trigeminal neuralgia (6).

A 2017 preclinical study found that CBD has benefits for the cardiovascular system. The authors reported that healthy individuals (age 21–29) with hypertension caused by a stressful event showed lower blood pressure after taking CBD (7).

Since the majority of the studies on CBD and trigeminal neuralgia have been conducted on animal models and preclinical human samples, longitudinal clinical studies are needed to further prove CBD’s ability to treat the condition.

How Does CBD Oil Work for Trigeminal Neuralgia?

The benefits of CBD for trigeminal neuralgia are attributed to the human endocannabinoid system (ECS). The ECS is the major regulatory network engaged in maintaining homeostasis in the central nervous system, peripheral nervous system, immune system, and organs. The ECS contains receptors that are found throughout the body, including CB1, CB2, and glycine receptors.

Studies have found that the modulation of the ECS might promote the healthy functioning of biological processes, providing a wide range of therapeutic benefits.

For example, a study published in the Journal of Experimental Medicine found that modulating the ECS translates into therapeutic effects for pain management. The authors also mentioned that glycine receptors in the central nervous system are important targets for reducing neuropathic pain. According to the study, cannabinoids such as THC and CBD might enhance the activity of the glycine receptors, resulting in analgesic effects.

Glycine receptors are ion channels that control the transmission of pain signals from the nerve to the brain.

The study found that oral CBD products resulted in a binding glycine activity that lowered neuropathic pain and hyperalgesia in animal models.

The Pros and Cons of CBD Oil for Trigeminal Neuralgia

The Pros

  • Numerous studies have demonstrated the therapeutic potential of CBD in pain management thanks to its ability to modulate receptors in the ECS.
  • Researchers agree that CBD might strengthen nerve impulses and increase pain resistance.
  • Animal studies have found that oral CBD solutions might be useful in lowering one’s sensitivity to pain.
  • CBD can reduce blood pressure in healthy volunteers, indirectly reducing the risk of trigeminal neuralgia
  • Many international medical organizations agree that CBD is well-tolerated in humans and has a high safety profile.

The Cons

  • There is not enough clinical evidence to support CBD’s efficacy in treating trigeminal neuralgia
  • CBD has a few mild side effects, including dry mouth, reduced appetite, drowsiness, and CBD-induced drug interactions
  • According to one animal study, extremely high doses of CBD can cause liver toxicity. However, these results haven’t been confirmed on human subjects.

CBD vs. Alternative Treatments for Trigeminal Neuralgia

There are limited options when it comes to alternative treatments for trigeminal neuralgia. The alternative anticonvulsants, except for CBD, aren’t supported by scientific studies. Recently, acupuncture has been touted for its effectiveness in treating neuropathic pain. There are lots of reports from TN patients who claim to have successfully treated TN with acupuncture.

Acupuncture is part of traditional Chinese medicine that uses tiny needles to balance the energy flow within the body. Studies also mention acupuncture’s ability to support homeostasis in the ECS. However, direct studies are needed to find out how acupuncture affects cannabinoid receptors.

One study from Frontiers of Molecular Neuroscience has found that electroacupuncture increased receptor activity in the rat models of osteoarthritis, resulting in reduced pain. Electroacupuncture is performed by sending electric signals through the microneedles (8).

Weird as it may sound, CBD has similar effects on the body to electroacupuncture. One study has found that the modulation of adenosine receptors resulted in mitigated pain and lower inflammation in mice after they took CBD (9).

Vitamin B12 is another alternative for trigeminal neuralgia. Research shows that vitamin B12 has painkilling properties that may aid patients in managing neuropathic pain.

Several clinical studies have reported positive results after treating patients with methylcobalamin, a form of B12. These studies examined patients with different types of neuropathy, such as trigeminal neuralgia and diabetic neuropathy (10).

How to Take CBD Oil for Trigeminal Neuralgia?

CBD comes in different forms, concentrations, and formulas. It may be taken orally in the forms of capsules or gummies, or sublingually as oil drops. Some people vape CBD, while others use it topically for localized relief. The choice of the product boils down to your individual situation.

CBD oil is the most common format. It contains a hemp extract infused into an inert oil, such as MCT oil or olive oil. CBD oil comes with a dropper for easier and more accurate dosing. You just squeeze the preferred amount using the dropper, place a few drops under your tongue, and wait for up to 60 minutes until it absorbs through tiny capillaries in your mouth. The calming effects of CBD should be felt within 15–20 minutes.

If you don’t like the taste of CBD oil, capsules and edibles are a good alternative. CBD capsules are available in the form of soft gels, providing a fixed dose of CBD per serving. They are better suited for busy people who take their CBD on the go. Since the CBD needs to pass through the digestive system before absorbing into the bloodstream, capsules have a delayed onset, usually around 40–90 minutes depending on your metabolism and whether or not you’re taking CBD oil on an empty stomach.

Edibles work in a similar fashion, but they are made with fun flavors that make the whole experience more enjoyable. The most popular forms of CBD edibles are gummies and honey sticks.

If you’re looking for the most effective way to deliver CBD to your system, CBD vape pens will be your best bet. Vaporized CBD gets into the bloodstream through the lung tissue, producing its effects within minutes after inhalation. CBD vapes also offer the highest bioavailability of all consumption methods, ensuring that up to 56% of the ingested substance is absorbed.

Finally, you may try a topical formulation, such as CBD creams for localized relief. Topicals work best for flare-ups because they address inflammation by interacting with the CB2 receptors in the skin’s endocannabinoid system. The absorption rate and duration of CBD topicals vary between products; you may need to reapply the dose after a few hours for consistent results.

Dosage of CBD Oil for Trigeminal Neuralgia

There are not enough clinical trials to determine the effective CBD dosage for specific health conditions.

According to a study published in the British Journal of Pharmacology, a low dose may vary from less than 1 to 50 milligrams per one kilogram per day. Everybody is different, and factors like your age, gender, metabolism, weight, overall health, and prior experience with CBD will affect your optimal dosage range.

It will take some experimentation until you find out what works for you. It is recommended to start with a low dose, say, 10 mg of CBD once or twice daily for one week — and observe the results. If you don’t feel any pain relief after that time, add another 10 mg to the dosage and continue for another week. Once you’ve found an effective dose, you can stick to it — people don’t build a tolerance to CBD.

If you’re thinking about adding CBD oil to your trigeminal neuralgia treatment, consult a holistic doctor experienced in CBD and cannabis therapies in general. Doing so will help you determine the right dosage range for your condition on top of avoiding potential negative CBD-induced drug interactions.

Summarizing the use of CBD for Trigeminal Neuralgia

Studies support CBD’s therapeutic effects in a range of painful conditions, including neuropathic pain. CBD modulates the activity of the cannabinoid receptors in the ECS, mitigating pain signals and reducing inflammation throughout the body. Moreover, CBD has been found to reduce blood pressure when administered under stressful conditions. All these effects can have a positive impact on the symptoms of trigeminal neuralgia. CBD is also an acknowledged anticonvulsant and neuroprotectant, so it can prevent further damage to the trigeminal nerve.

More direct clinical trials are needed to prove CBD’s efficacy specifically in alleviating TN pain. However, current findings, as well as reports from patients, are very encouraging.

Do you take CBD for trigeminal nerve pain? What products work best for you? Share your thoughts in the comment section!

Literature:

  1. Pacher, Pál et al. “The endocannabinoid system as an emerging target of pharmacotherapy.” Pharmacological reviews vol. 58,3 (2006): 389-462. doi:10.1124/pr.58.3.2
  2. Liang, Ying-Ching et al. “Therapeutic potential of cannabinoids in trigeminal neuralgia.” Current drug targets. CNS and neurological disorders vol. 3,6 (2004): 507-14. doi:10.2174/1568007043336833
  3. Turner, C L et al. “Measurement of pulse pressure profiles in patients with trigeminal neuralgia.” Journal of neurology, neurosurgery, and psychiatry vol. 74,4 (2003): 533-5. doi:10.1136/jnnp.74.4.533
  4. The U.S. Food and Drug Administration. The FDA Approves First Drug Comprised of Cannabidiol.
  5. Costa, Barbara et al. “The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain.” European journal of pharmacology vol. 556,1-3 (2007): 75-83. doi:10.1016/j.ejphar.2006.11.006
  6. Trigeminal Neuralgia Overview.
  7. Jadoon, Khalid A et al. “A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.” JCI insight vol. 2,12 e93760. 15 Jun. 2017, doi:10.1172/jci.insight.93760
  8. Yuan, Xiao-Cui et al. “Electroacupuncture Potentiates Cannabinoid Receptor-Mediated Descending Inhibitory Control in a Mouse Model of Knee Osteoarthritis.” Frontiers in molecular neuroscience vol. 11 112. 6 Apr. 2018, doi:10.3389/fnmol.2018.00112
  9. Russo, Ethan B. “Cannabinoids in the management of difficult to treat pain.” Therapeutics and clinical risk management vol. 4,1 (2008): 245-59. doi:10.2147/term.s1928
  10. Zhang, Ming et al. “Methylcobalamin: a potential vitamin of pain killer.” Neural plasticity vol. 2013 (2013): 424651. doi:10.1155/2013/424651
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Livvy Ashton

Livvy is a registered nurse (RN) and board-certified nurse midwife (CNM) in the state of New Jersey. After giving birth to her newborn daughter, Livvy stepped down from her full-time position at the Children’s Hospital of New Jersey. This gave her the opportunity to spend more time writing articles on all topics related to pregnancy and prenatal care.

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How CBD May Help With Trigeminal Neuralgia

TN ( trigeminal neuralgia ) is a medical condition characterized by chronic pain from the trigeminal nerve , which carries sensation from the face to the brain (1) .

CBD’s activity in the ECS ( endocannabinoid system ) may explain how this non-psychoactive compound may help with chronic pain and conditions like trigeminal neuralgia .

The ECS is vital to the CNS ( central nervous system ) and plays a role in regulating pain and inflammation (2) .

The ECS consists of cannabinoid receptors type 1 and 2 (CB1 and CB2), endocannabinoids, and enzymes.

Cannabinoids , like CBD and THC , may exert their antinociceptive properties through complex mechanisms involving effects on the CNS, spinal cord , and peripheral sensory nerves (3) .

Antinociceptive agents are compounds that can diminish pain without adverse effects on consciousness.

CB1 receptors play a key role in pain sensation (4) . Meanwhile, recent studies suggest that CB2 receptors may be involved in the antihyperalgesic activity of cannabinoids in acute, chronic, and neuropathic pain (5) .

Antihyperalgesic activity refers to the ability of certain compounds to counteract hyperalgesia or extreme sensitivity to pain.

Although CBD has a low binding affinity for both cannabinoid receptors , it may antagonize them in the presence of THC (6) .

The non-psychoactive compound may also regulate pain perception (7) . Thus, CBD may help with painful conditions such as trigeminal neuralgia .

Opioids are medications for persistent or severe pain. Despite their high potential for abuse, these prescription drugs are used mostly as an adjunct to anticonvulsants (8) .

Opioids are also prevalent in patients with facial pain, including those who have TN (9 ) .

However, opioid abuse has become a national crisis in the United States, in which 90 Americans die by overdose each day (10) . For this reason, more studies are exploring the use of cannabis as a substitute for opioids (11 ) .

Cannabis refers to a group of plants, such as Cannabis sativa, Cannabis indica, and Cannabis ruderalis. These plants have more than 100 chemical components known as cannabinoids.

THC ( tetrahydrocannabinol ) and CBD ( cannabidiol ) are among the phytocannabinoids (plant-based cannabinoids) found in cannabis plants .

THC is the principal psychoactive compound of cannabis . The compound is responsible for the euphoric high users’ experience.

A study published in 2021 noted that, unlike opioids, cannabis has no reported deaths due to overdodse (12) .

Meanwhile, CBD is non-psychoactive. Some studies also suggest that CBD may antagonize at least some of the adverse effects of THC (13) .

The non-psychoactive compound has been of particular interest as a target for opioid use disorder (14) .

In a survey in California, about 80% of patients who used medical cannabis either as a substitute or in conjunction with opioid -based pain medication claimed that cannabis is more effective than opioids for pain (15) .

A study from the journal Neurology assessed the efficacy of medical cannabis in patients with trigeminal neuralgia ( 16) .

Of the 42 patients with TN, 81% reported improvements in their symptoms, while 50% said they reduced their opioid consumption with medical cannabis (17 ) .

The most efficacious dosage for the patients involved was a 1:1 ratio of THC to CBD (18) .

Although CBD may not be a standalone treatment for chronic pain , it is believed that using CBD as an adjunct therapy may provide pain relief , reduce the amount of opioid medication a patient is taking, and improve the overall quality of life (19) .

Benefits of Using CBD for Trigeminal Neuralgia

Cannabidiol has been shown to have anti-inflammatory and analgesic properties (20) . These potential health benefits may help individuals with trigeminal neuralgia .

TN is inflammation of the trigeminal nerve , a large three-part nerve in the head that provides sensation. It is a form of neuropathic pain associated with nerve lesions or nerve injuries.

It is believed that trigeminal nerve pain may be triggered by the contraction of blood vessels in the trigeminal nerve , damaging the trigeminal protective tissue (21) .

For individuals with TN, even mild stimulation of their faces, such as putting on makeup or brushing their teeth, may trigger an excruciating pain similar to an electric shock (22) .

A study from the European Journal of Pharmacology examined CBD’s efficacy in rat chronic inflammatory and neuropathic pain (23) .

The researchers administered 2.5-20 mg of CBD to neuropathic models and 20 mg of CBD to adjuvant-injected rats from days 7 to 14.

An adjuvant is an ingredient that may help create a more robust immune response in individuals receiving vaccines.

The findings indicated a potential for the therapeutic use of CBD in chronic painful states (24) .

It has been demonstrated that trigeminal neuralgia is common in patients with MS ( multiple sclerosis ), a disease that particularly affects the brain and spinal cord (25) .

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Pain is a common symptom in multiple sclerosis , and about 75% of MS patients experience it (26) .

An elevated relative risk has also been associated with high blood pressure , particularly among women with trigeminal neuralgia (27) .

Preclinical studies showed that CBD may reduce blood pressure response to stress (28) .

These studies seem promising. However, they are either based on animal research or small clinical trials .

Still, the findings may be useful to researchers conducting further studies on CBD’s efficacy in painful conditions , like trigeminal neuralgia .

How to Take CBD for Trigeminal Neuralgia

Below are standard delivery methods by which CBD is taken into the body (29) :

  • Inhalation ( vape pens)
  • Ingestion ( edibles like gummies and capsules)
  • Sublingual or under the tongue ( tinctures , strips, tablets, and sprays)
  • Topical ( CBD creams , salves, lotions, and balms)

TN patients may initially experience mild attacks that can progress to more-frequent bouts of pain (30) .

Inhaling CBD using vape pens is the quickest way to benefit from the compound. CBD usually takes effect within two to 15 minutes via the inhalation route (31-32) . However, vaping may damage the lungs (33) .

Hence, talk with a healthcare professional experienced in cannabis use to determine which delivery route is best for trigeminal neuralgia or any health conditions .

CBD Dosage

The FDA ( Food and Drug Administration ) has not approved CBD as a treatment for trigeminal neuralgia . Hence, there is no standard CBD dosage for such a condition.

The general rule is to start with low doses . However, it is believed that mid-range doses between 10mg and 100mg of CBD daily may help with pain management (34) .

Still, it is best to talk with a healthcare professional with a background in cannabis use and dosing . They can advise you regarding the proper CBD dosage for trigeminal neuralgia .

How Long Does CBD Take to Help Trigeminal Neuralgia ?

How long it takes for cannabidiol to help with TN depends on several factors like the route of administration used, individual body weight, and CBD potency.

If you choose to take CBD via the inhalation route, expect to feel CBD’s effect within two to 15 minutes (35) . Meanwhile, when taken sublingually, the effects of CBD take much longer, usually between 15 and 30 minutes (36) .

How Long Will CBD Help With Trigeminal Neuralgia ?

How long CBD will last after it takes effect depends on its half-life and bioavailability.

Half-life is the time needed for the concentration of a specific substance to decrease by 50% of its starting dose in the body. It is believed that 94% to 97% of a drug will have been eliminated following four to five half-lives (37) .

The half-life of CBD was reported between 1.4 and 10.9 hours after oromucosal spray and 31 hours following smoking (38) .

Meanwhile, bioavailability is the extent to which a particular drug becomes entirely available to its biological destination.

The bioavailability of CBD following smoking is 31% (39) . The bioavailability of cannabidiol when taken under the tongue is between 6% and 20% (40) .

Choosing the Best CBD Oil for Trigeminal Neuralgia

Most CBD companies are determined to provide high-quality CBD products like CBD oil for trigeminal neuralgia and overall wellness .

With many CBD brands promising the same thing, choosing the right product for you can be challenging.

Below are a few pertinent things to consider before buying any CBD product :

CBD Extracts

A full-spectrum CBD oil includes all the compounds of the cannabis plant , including CBD and other cannabinoids , essential oils, terpenes , and flavonoids.

A full-spectrum CBD provides the entourage effect, the theory wherein the biologically active compounds of cannabis work better together. Its THC concentration is also less than 0.3%.

Terpenes are aromatic compounds present in cannabis and many other plants. Flavonoids are plant chemicals with purported anti-inflammatory , antioxidant, and antiviral actions (41) .

A broad-spectrum CBD oil is almost the same as the full spectrum. However, it is nearly THC -free. Meanwhile, CBD isolates are made of pure CBD.

Ingredients

Check the ingredients to find out if there are any possible allergens or additives that may adversely affect you.

Generally, CBD products are infused with carrier oils, including MCT (medium-chain triglycerides) oil, coconut oil, and hempseed oil.

CBD Strength and Potency

The COA (certificate of analysis) is a document that indicates the amount of CBD, THC , and other ingredients in a CBD product .

The CBD company you choose must enlist the services of a third-party laboratory to check all products , ensuring objectivity and transparency.

Extraction Method

Carbon dioxide extraction , ethanol extraction , or solvent extraction with olive oil are preferred methods to create a safe CBD product (42) .

On the other hand, extraction techniques using hexane or butane may leave harmful residues.

Brand Reputation

Always purchase CBD products from a reputable store or dispensary authorized to sell CBD products .

Read customer feedback to get more insight about the manufacturer and its products.

The Potential Risks and Side Effects of Using CBD for Trigeminal Neuralgia

CBD is relatively safe and is well tolerated in humans and animals (43) . Still, the compound may induce risks and minor side effects , including (44) :

  • Dry mouth
  • Diarrhea
  • Reduced appetite
  • Drowsiness
  • Fatigue

The first-line treatment for trigeminal neuralgia is anticonvulsant medical therapy (45) . However, these drugs, primarily used to treat epileptic seizures, may interact with CBD (46) .

At high doses, CBD may inhibit the activity of cytochrome P450, a family of liver enzymes that metabolize about 60% of pharmaceutical drugs people consume (47) .

Antiepileptics or anticonvulsants use the cytochrome P450 enzyme system, which explains their possible interaction with CBD (48) .

Legality of CBD

The 2018 Farm Bill indicates that Cannabis sativa L. and other derivatives of cannabis with less than 0.3% THC on a dry weight basis are federally legal in the United States (49) .

In addition, some states like Colorado have passed laws allowing recreational and medical marijuana use. Still, these state laws do not change the fact that marijuana is listed as a Schedule I drug under federal law (50-51) .

Some states may even require a medical marijuana card to purchase cannabis products from authorized dispensaries . Therefore, make sure to research state legislations concerning cannabis use to avoid legal repercussions.

Product Frequently
Asked Questions

How can CBD help with trigeminal neuralgia?

There is no direct study suggesting that CBD can help with TN ( trigeminal neuralgia ).

However, CBD may be effective in different types of pain due to its analgesic properties (52) . The non-psychoactive compound may also help with several neurological disorders (53) .

TN is a rare neurological condition that causes chronic and severe facial pain (54) . A person with such a condition may feel burning sensations in the face.

As mentioned, CBD has pain-relieving effects (55) . These properties may help with painful conditions like trigeminal neuralgia .

What evidence or research exists to say that CBD helps with trigeminal neuralgia?

A 2019 study suggested that medical cannabis may be a valuable part of a comprehensive pain management plan for TN patients (56) . Researchers reported that the 1:1 ratio of THC to CBD is the most effective dosage among these patients.

Although CBD may not be a standalone treatment for chronic pain caused by various medical conditions like TN, the compound may provide pain relief to people and therefore contribute to their improved quality of life (57) .

Is there any evidence that CBD can make trigeminal neuralgia worse?

No evidence suggests that CBD can make trigeminal neuralgia worse. However, CBD may still induce risks and side effects like fatigue (58) .

Will CBD interact with any current medication I may be taking for trigeminal neuralgia?

CBD may interact with other medications like anticonvulsants , which are first-line treatments for TN (59-60) .

At high doses, CBD may inhibit the activity of cytochrome P450, a family of liver enzymes that metabolize about 60% of pharmaceutical drugs people consume (61) .

Antiepileptics or anticonvulsants use the cytochrome P450 enzyme system, which explains their possible interaction with CBD (62) .

Are there other treatments I should consider alongside CBD to help with trigeminal neuralgia?

Painkillers like paracetamol are ineffective in managing pain associated with TN. One type of pain relief medication prescribed to TN patients is an anticonvulsant (63) .

Muscle-relaxing agents may also be used to help with TN. However, their side effects include drowsiness, confusion, and nausea (64) .

Thus, ensure to talk with your doctor if you consider other treatments alongside CBD to help manage TN symptoms.

Can I fail a drug test if I use CBD for trigeminal neuralgia?

CBD does not cause euphoria (65) . Still, some CBD products have small amounts of THC that may build up in the body when taken regularly in a span of four to six days (66) .

An increased THC level in the bloodstream may result in a positive drug test.

What is the dosage for trigeminal neuralgia?

There is no standard CBD dosage for TN. However, doses between 10mg and 100mg may help with pain management (67) . TN is characterized by chronic pain (68) .

How should I use CBD oil for trigeminal neuralgia?

Inhaling CBD using vape pens usually takes effect within 2 to 15 minutes via the inhalation route (69) . However, extra caution is needed as vaping may damage the lungs (70) .

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