Can You Take CBD Oil With Cymbalta


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Contributor: Dr. Augustine Provencio, MD CBD and Cymbalta explained. When finding treatment for common illnesses like chronic pain and anxiety, the search Products containing cannabidiol (CBD) are very popular, promising relief from a wide range of maladies. But if you are considering taking a product containing CBD, be aware that if you are taking any other prescription or over-the-counter medications, supplements, or herbal products, CBD can interact with them and cause unexpected … Can You Take CBD Oil With Cymbalta? Drug interaction is defined as the changes in a drug’s effects due to recent or concurrent use of another drug or drugs (drug-drug interactions), ingestion of

CBD and Cymbalta

CBD and Cymbalta explained. When finding treatment for common illnesses like chronic pain and anxiety, the search for a substance that works can be frustrating to patients, and in cases, worsen already existing side effects.

Cymbalta, also known as Duloxetine, is a prescription medication used to treat symptoms of anxiety, depression, and Fibromyalgia. CBD, another well know substance, is paving the way as a new revolutionary drug to help treat a variety of diseases. Here we will discuss CBD and its reaction / potential side effects when mixed with Cymbalta.

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What Does Cymbalta Treat

Anxiety and depression affect the sufferers physical and emotional responses to stressors and stimuli, often creating negative (and in many cases involuntary) responses to seemingly insignificant triggers. Fibromyalgia, or a tight pain in muscles and pressure points throughout the body, can be both caused by and cause anxiety-like symptoms.

Why Compare Cymbalta and CBD

Some patients using Cymbalta have begun to look to CBD as a method of increasing the positive effects of the drug such as pain and anxiety relief, or in other cases hope that the addition of CBD will make it possible to lower or change their Cymbalta dosage with less harsh side effects. Navigating the dosage and alteration of treatment can be tricky, which has raised questions of just how effective CBD is in relation to Cymbalta and whether or not pairing the two is a safe choice. CBD has been observed to help patients with both anxiety and pain, prompting closer examination of the interactions CBD can have with Cymbalta.

How Does Cymbalta Work Chemically

Cymbalta, similar to CBD, interacts with the Serotonin centers in the brain. Cymbalta is a serotonin-norepinephrine reuptake inhibitor. The delayed release capsules stimulate serotonin centers which help to create a calming effect and elevate mood. Specifically, Cymbalta prevents brain cells from quickly absorbing neurotransmitters and sending overactive messages of panic and fear to the body known as fight or flight responses. These responses include symptoms of both anxiety and Fibromyalgia. Muscle pain and tension typical to Fibromyalgia sufferers can be brought about by panic attacks.

How Does CBD Work Chemically

CBD functions in a similar way to Cymbalta, working with receptors that trigger fear responses and bodily reactions (muscle tension, headaches etc.) By interacting with the parts of the brain responsible for symptoms of anxiety and Fibromyalgia, substances like Cymbalta can lessen the severity of these symptoms. Many CBD users have have reported to notice relief for these same symptoms from using CBD oil.

Possible Side Effects of Cymbalta

A major concern in mixing CBD and Cymbalta is how CBD can exasperate already possible negative side effects. Side effects largely depend on the individual patient, their chemical makeup, and what Cymbalta is prescribed to them for. These side effects include:

  • Nusea
  • Dry Mouth
  • Fatigue
  • Loss of Appetite
  • Sweating
  • Increased anxiety or panic attacks
  • Increased depression
  • Suicidal thoughts

Other Cymbalta Concerns

Some patients prescribed Cymbalta have reported withdrawal symptoms after stopping the medication. This reaction is not uncommon after discontinuation of depression and anxiety medications, which is another strong reason that some patients have begun to try CBD. CBD oil can help with withdrawal effects while presenting no withdrawal effects of its own. Read more about patients reports on Cymbalta withdraws here.

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How Do CBD and Cymbalta Interact

Some observations have noticed moderate interaction between CBD / Cannabis products and Cymbalta. While there are no fatal or extremely internally hazardous interactions noted to date, CBD and Cymbalta can cause complications when used together for the treatment of anxiety or chronic pain. Among these interactions are:

  • Dizziness
  • Confusion
  • Lack of Concentration
  • Impaired Judgement
  • Loss of memory

These symptoms are noted to be worse in elderly users.

Mixing Cymbalta and CBD

In terms of mixing CBD and Cymbalta for anxiety, it may be helpful for cases of insomnia (or sleeplessness brought on by moderate to severe pain) but presents risks for users when functioning through normal daily activities. CBD and Cymbalta together present largely sedative interactions.

Studies of CBD and Fibromyalgia

Fibromyalgia is one of the main ailments Cymbalta is prescribed for. Though CBD and Cymbalta are not extremely beneficial together, patients concerned about potential withdrawal from Cymbalta do have the option of turning to CBD as an alternative medication. A recent study tested cannabis products against three Fibromyalgia medications including Cymbalta and found that 62% of patients tested found CBD to be a helpful treatment for chronic pain.

CBD as Long-term Pain Relief Alternative

Other patients who have not found relief in major FDA approved drugs have reported some positive findings when using CBD to tried their Fibromyalgia related pain. One user expressed that she did feel significant relief after years of searching, but did warn that buyers should closely monior the quality of the CBD they buy. Good CBD may be more expensive, but when taking the place of a larger drug like Cymbalta, the cost was worth it.


Taking CBD with Cymbalta has not been observed to have inherently lethal or harmful side effects, however, some of the side effects noted can make it difficult to perform daily tasks like driving, operating machinery, and making decisions. These interactions have been especially prominent in elderly users. When compared to Cymbalta as a treatment option for Fibromyalgia, users have found proportionately positive results. CBD offers a treatment that has been observed to be effective in treating pain while avoiding the difficult withdrawal symptoms some Cymbalta users have suffered.

How to Try Safely

Before making any changes to your treatment for anxiety, depression, or Fibromyalgia, it is important to consult your doctor and make your interest in CBD as an alternative known. Only a medical professional can properly help in balancing dosages and alerting you to and possible adverse reactions you may not have been aware of. As with any medication, figuring out the exact dose and frequency that will be most effective for your symptoms may take time, and communicating your goals, experiences, and preferences clearly with your doctor. As more studies are conducted on CBD as a treatment option, more possibilities become clear. If you have found little relief from taking Cymbalta, or are looking to make a change with less withdrawal symptoms, CBD may be an option to consider.

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CBD and other medications: Proceed with caution

Products containing cannabidiol (CBD) seem to be all the rage these days, promising relief from a wide range of maladies, from insomnia and hot flashes to chronic pain and seizures. Some of these claims have merit to them, while some of them are just hype. But it won’t hurt to try, right? Well, not so fast. CBD is a biologically active compound, and as such, it may also have unintended consequences. These include known side effects of CBD, but also unintended interactions with supplements, herbal products, and over-the-counter (OTC) and prescription medications.

Doubling up on side effects

While generally considered safe, CBD may cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth, and, in rare instances, damage to the liver. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time with OTC or prescription medications and substances that cause sleepiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol may lead to increased sleepiness, fatigue, and possibly accidental falls and accidents when driving. Increased sedation and tiredness may also happen when using certain herbal supplements, such as kava, melatonin, and St. John’s wort. Taking CBD with stimulants (such as Adderall) may lead to decreased appetite, while taking it with the diabetes drug metformin or certain heartburn drugs (such as Prilosec) may increase the risk of diarrhea.

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CBD can alter the effects of other drugs

Many drugs are broken down by enzymes in the liver, and CBD may compete for or interfere with these enzymes, leading to too much or not enough of the drug in the body, called altered concentration. The altered concentration, in turn, may lead to the medication not working, or an increased risk of side effects. Such drug interactions are usually hard to predict but can cause unpleasant and sometimes serious problems.

Researchers from Penn State College of Medicine evaluated existing information on five prescription CBD and delta-9-tetrahydrocannabinol (THC) cannabinoid medications: antinausea medications used during cancer treatment (Marinol, Syndros, Cesamet); a medication used primarily for muscle spasms in multiple sclerosis (Sativex, which is not currently available in the US, but available in other countries); and an antiseizure medication (Epidiolex). Overall, the researchers identified 139 medications that may be affected by cannabinoids. This list was further narrowed to 57 medications, for which altered concentration can be dangerous. The list contains a variety of drugs from heart medications to antibiotics, although not all the drugs on the list may be affected by CBD-only products (some are only affected by THC). Potentially serious drug interactions with CBD included

  • a common blood thinner, warfarin
  • a heart rhythm medication, amiodarone
  • a thyroid medication, levothyroxine
  • several medications for seizure, including clobazam, lamotrigine, and valproate.

The researchers further warned that while the list may be used as a starting point to identify potential drug interactions with marijuana or CBD oil, plant-derived cannabinoid products may deliver highly variable cannabinoid concentrations (unlike the FDA-regulated prescription cannabinoid medications previously mentioned), and may contain many other compounds that can increase the risk of unintended drug interactions.

Does the form of CBD matter?

Absolutely. Inhaled CBD gets into the blood the fastest, reaching high concentration within 30 minutes and increasing the risk of acute side effects. Edibles require longer time to absorb and are less likely to produce a high concentration peak, although they may eventually reach high enough levels to cause an issue or interact with other medications. Topical formulations, such as creams and lotions, may not absorb and get into the blood in sufficient amount to interact with other medications, although there is very little information on how much of CBD gets into the blood eventually. All of this is further complicated by the fact that none of these products are regulated or checked for purity, concentration, or safety.

The bottom line: Talk to your doctor or pharmacist if using or considering CBD

CBD has the potential to interact with many other products, including over-the-counter medications, herbal products, and prescription medications. Some medications should never be taken with CBD; the use of other medications may need to be modified or reduced to prevent serious issues. The consequences of drug interactions also depend on many other factors, including the dose of CBD, the dose of another medication, and a person’s underlying health condition. Older adults are more susceptible to drug interactions because they often take multiple medications, and because of age-related physiological changes that affect how our bodies process medications.

People considering or taking CBD products should always mention their use to their doctor, particularly if they are taking other medications or have underlying medical conditions, such as liver disease, kidney disease, epilepsy, heart issues, a weakened immune system, or are on medications that can weaken the immune system (such as cancer medications). A pharmacist is a great resource to help you learn about a potential interaction with a supplement, an herbal product (many of which have their own drug interactions), or an over-the-counter or prescription medication. Don’t assume that just because something is natural, it is safe and trying it won’t hurt. It very well might.

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Can You Take CBD Oil With Cymbalta?

Drug interaction is defined as the changes in a drug’s effects due to recent or concurrent use of another drug or drugs (drug-drug interactions), ingestion of food (drug-nutrient interactions), or ingestion of dietary supplements (dietary supplement-drug interactions).

Drug-drug interactions result when two or more drugs react with each other. Such drugs can be from a combination of prescription drugs and/or over-the-counter (OTC) medications. Drugs with a narrow therapeutic range (little difference between therapeutic and lethal dose) are more likely to face incidents of serious drug interactions.

What is CBD oil?

Cannabidiol (CBD) oil is a product that’s derived from cannabis. It’s a type of cannabinoid, which are the chemicals naturally found in marijuana plants. Even though it comes from marijuana plants, CBD doesn’t create a “high” effect or any form of intoxication — that’s caused by another cannabinoid, known as THC. This quality makes CBD an appealing option for those who are looking for relief from pain and other symptoms without the mind-altering effects of cannabis or other side effects related to some pharmaceutical drugs.

CBD oil is made by extracting CBD from the cannabis plant and then diluting it with a carrier oil like coconut oil or hemp seed oil. CBD can be found in a variety of products online and in stores, including dietary supplements, bath soaks, drinks, and food.

It continues to gain momentum in the health and wellness world, with some scientific studies finding that it may ease symptoms of conditions such as chronic pain and anxiety. CBD has shown promise in initial studies as a treatment for both depression and anxiety, and it may cause fewer side effects in some people.

The findings of research may help explain why CBD could be useful in treating depression. They indicate that, in most studies, CBD appears to have a positive interaction with serotonin receptors in the brain. Serotonin impacts a range of functions in the body, including a person’s emotional state and feelings of well-being or happiness. Keeping serotonin levels balanced is often a key therapy for people with depression.

What is Cymbalta?

Cymbalta is a brand of duloxetine, a selective serotonin, and norepinephrine reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may be unbalanced in people with depression. Cymbalta is used to treat major depressive disorder in adults. It is also used to treat general anxiety disorder in adults and children who are at least 7 years old.

Cymbalta is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Cymbalta is also used to treat fibromyalgia (a chronic pain disorder) in adults and children at least 13 years old.

Duloxetine comes as a delayed-release (releases the medication in the intestine to prevent break-down of the medication by stomach acids) capsule to take by mouth. When duloxetine is used to treat depression, it is usually taken once or twice a day with or without food.

Can You Take CBD Oil With Cymbalta?

No, using CBD oil and Cymbalta together may increase the risk of side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.

In addition, CBD oil can interfere with the liver enzymes that break down Cymbalta, their interactions may lead to insufficient concentrations of the drug in the body and affect how the medication works. In severe cases, using CBD oil and Cymbalta together can lead to liver failure and or serotonin syndrome which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea.

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